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Scientists at the Walter Reed Army Institute for Research have shown that microRNA biomarkers related to Alzheimer s disease play a role in brain damage caused by traumatic brain injury.
TBI or brain trauma results from blows to the head, leading to chronic disruption of the brain and a cascade of long-term health conditions. Patients who suffer from TBI are at much higher risk of developing neurodegenerative disease or dementia, particularly Alzheimer s disease. The mechanism behind this relationship remains understudied, making the development effective therapeutics challenging.
MiRNAs are small pieces of genetic material that play a critical role in normal gene expression. Yet, studies have also linked abnormal miRNA levels, or dysregulation, to a range of diseases including neurodegenerative disorders and cell death after TBI, making them a subject of great interest to researchers who hope to use them as biomarkers and novel targets of drug therapies.
New research from Washington University School of Medicine in St. Louis indicates that allergens in the environment often are to blame for episodes of acute itch in eczema patients, and that the itching often doesn t respond to antihistamines because the itch signals are being carried to the brain along a previously unrecognized pathway that current drugs don t target.
Researchers demonstrate great potential for blood test to detect, monitor Alzheimer s disease
In three recent publications in
Brain and
JAMA Neurology researchers from the University of Gothenburg provide convincing evidence that an in-house developed blood test for Alzheimer s disease can detect the disease early and track its course, which has major implications for a potential use in clinical practice and treatment trials.
This is an extremely dynamic research field right now, thanks to the technological development and seminal scientific progress in the past years. The dream scenario is to have a blood test for the early detection and screening of Alzheimer s disease up and running. That would give significantly more people in the world access to testing and future treatments.
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IDSA Foundation Announces More Than $1 Million in Grant Funds for Researchers Linking Infectious Agents in Alzheimerâs Disease
Newswise ARLINGTON, Va. (January 12, 2021) – Ten researchers who are exploring the link between an infectious agent and Alzheimer’s disease have each been awarded $100,000 research grants through the IDSA Foundation’s Microbial Pathogenesis in Alzheimer’s Disease Grant program. Since the program was established in 2018, the IDSA Foundation has provided more than $600,000 to seven researchers, making the 2020 awardees the largest recipient pool to date. The program will provide an additional pilot grant of $8,000 to begin research and initial data collection for a dementia study in Uganda.